Brain Diseases and Metalloproteins
by David R. Brown (University of Bath, UK)
Hardback 438 pages 2012-07-31 Print ISBN: 9789814316019 eBook ISBN: 9789814364072 DOI: 10.4032/9789814364072
List price : $179.95
"This is an authoritative and thorough overview of a field of growing significance to neuroscience. Metal ion metabolism is intimately involved with the causes of most neurodegenerative disease, and is an area of unexploited importance for potential drug development. This work is timely, and tremendously useful with an excellent choice of subjects, beautifully and rigorously presented."
Prof. Ashley I. Bush - University of Melbourne, Australia
The incidence of brain diseases brings with it a shocking increase in social and economic burden, which necessitates a greater effort to understand these diseases and find ways to manage, alleviate, or even prevent them. Basic research is key to changing assumptions and to challenging our views about the cause of these diseases, which make up a very large family. This book is a conscientious, thorough, and painstaking attempt to approach the most debilitating conditions that strip away the very fabric of who we are.
A world-class compilation of 11 chapters written by experts in neurodegenerative diseases, this book is an exhaustive study of proteins—now known as metal binding proteins—that cause these anomalies. This is one of the leading fields of new research into brain diseases, and a lot of novel and interesting insights have been gained that may one day lead to the treatment of the most frightening sets of brain conditions that exist. The book contains latest research from leading experts in the field who work on aspects ranging from pure chemistry of metal binding to clinical aspects of the diseases and the use of chelators in possible treatment. A strong emphasis on biochemistry and cell biology make this study all the most interesting and topical. The diseases covered include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters examine such issues as mechanisms of metal binding, metal induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.
|1||Chapter 1: Introduction|
David R. Brown
|11||Chapter 2: A Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease|
Brian J. Tabner, Susan Moore, Jennifer Mayes, and David Allsop
|33||Chapter 3: Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration|
Ewa Gralka, Daniela Valensin, Maurizio Remelli, and Henryk Kozlowski
|81||Chapter 4: Mammalian Metallothioneins|
Duncan E. K. Sutherland and Martin J. Stillman
|137||Chapter 5: Copper Transporting P-Type ATPases in the Brain|
Sharon La Fontaine, James Camakaris, and Julian Mercer
|169||Chapter 6: Role of the Amyloid Precursor Protein and Copper in Alzheimer’s Disease|
Loredana Spoerri, Kevin J. Barnham, Gerd Multhaup and Roberto Cappai
|221||Chapter 7: Role of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer’s Disease|
Silvia Bolognin and Paolo Zatta
|249||Chapter 8: Prion Diseases, Metals and Antioxidants|
Paul Davies and David R. Brown
|295||Chapter 9: Emerging Role for Copper-Bound ?-Synuclein in Parkinson’s Disease Etiology|
Heather R. Lucas and Jennifer C. Lee
|327||Chapter 10: Interactions of ?-Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson’s Disease|
Andrés Binolfi and Claudio O. Fernández
|367||Chapter 11: An Attempt to Treat Amyotrophic Lateral Sclerosis by Intracellular Copper Modification Using Ammonium Tetrathiomolybdate and/or Metallothionein: Fundamentals and Perspective|
Shin-Ichi Ono, Ei-Ichi Tokuda, Eriko Okawa, and Shunsuke Watanabe
Experts working the in fields of metallochemistry or neurodegeneration (i.e., biologists and chemists). University students of specialist courses relating to these fields.
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