Scaffolds for Tissue Engineering - Biological Design, Materials, and Fabrication
by Claudio Migliaresi (University of Trento, Italy), Antonella Motta (University of Trento, Italy)
Hardback 680 pages 2014-05-31 Print ISBN: 9789814463201 eBook ISBN: 9789814463218 DOI: 10.4032/9789814463218
List price : $249.95
“The book Scaffolds for Tissue Engineering: Biological Design, Materials and Fabrication, edited by Migliaresi and Motta, is a very comprehensive textbook, with chapters written by many of the leaders in the tissue engineering field. The book begins with several chapters covering the structural and functional biology of body tissues, their healing processes and their regeneration. It then reviews synthetic and natural biomaterials that have been proposed for use as scaffolds, including body responses to the scaffolds. There are chapters on the fabrication of scaffolds and their evaluation in vitro and in vivo, which should be very useful for those developing tissue-engineered scaffolds. The book ends with a chapter looking towards the future commercialization of tissue-engineered scaffolds. In summary, this book should be useful for those doing research on tissue-engineered scaffolds, the companies developing new tissue-engineered products, and the clinicians looking to the future replacement of tissues in the clinic.”
Prof. Allan S. Hoffman - University of Washington, USA
“Scaffolds are an essential part of success in tissue engineering, although selection of the appropriate scaffold too frequently is a haphazard approach. The current volume, by dealing with many aspects of scaffold characteristics, provides an excellent basis to assist researchers in leaving the path of trial and error and designing scaffolds on the basis of true understanding. The book is very worthwhile and a must read for anybody interested in tissue engineering.”
Prof. Clemens A. van Blitterswijk - University of Twente, The Netherlands
“Tissue engineering is the most promising technology to treat various diseases by using cultured cells and will be a main actor in medical science in the 21st century. The fusion of medicine and engineering is essentially indispensable for tissue engineering, especially scaffold-based tissue engineering, although cell-sheet base tissue engineering is also important. At this timing, publishing this book is quite adequate, and it will be useful for those who have engineering, medical, and biological science background.”
Prof. Teruo Okano - Tokyo Women's Medical University, Japan
Scaffolds for tissue engineering are devices exploiting specific and complex physical and biological functions, in vitro or in vivo, communicating through biochemical and physical signals with cells and, when implanted, with the body environment.
Scaffolds can be produced with several materials, most of them of synthetic origin, with an increasing interests on the use of biological or nature-derived materials. In most cases fabrication technologies are derived from already well-established industrial processes, with some new specific technologies having been developed in the last years to address required complexities.
Often, a generalist approach is followed for the translation of materials and technologies designed for other applications, without considering the specific role of the scaffold from a physical and biological point of view. The book illustrates the scaffolds design principles with particular relevance to the biological requirements needed to control and drive the biological cross-talk, and reviews materials and fabrication and validation methods.
The book is mainly addressed to graduate and post-graduate students, who are approaching tissue engineering or experienced researchers who wish to have condensed but comprehensive information on materials, fabrication techniques, biological principles, and design criteria. The contributors are among the scientific leaders in their respective fields.
About the Editors:
Claudio Migliaresi is professor of composite materials engineering and of biomaterials and biomedical technologies, head of the Department of Industrial Engineering, dean of the School of Industrial Engineering, and head of the BIOtech Research Center of the University of Trento, Italy. His research activities range from composite materials to biodegradable polymers, biomaterials, materials, and scaffolds for tissue engineering. Prof. Migliaresi has published about 200 papers, edited the five volumes of the book Polymers in Medicine, and owns some patents.
Antonella Motta is assistant professor at the University of Trento and has qualified as associate professor of bioengineering by the Italian evaluation system. She teaches bioengineering and tissue engineering and regenerative medicine courses. Prof. Motta’s research activities are mainly focused on nature-derived polymers for tissue engineering applications, scaffold design, and interactions of material–biological systems. She has published about 90 papers, edited several chapters on tissue engineering, and owns some patents.
|1||Chapter 1: Overview: An Evolving State of the Art in Tissue Engineering|
Anthony T. DiBenedetto
|21||Chapter 2: The Functional Role of Extracellular Matrix|
Eleonora Carletti, Matteo Stoppato, Claudio Migliaresi, and Antonella Motta
|57||Chapter 3: The Premise of Tissue Engineering: Molecular Recognition|
Christopher J. Pateman and John W. Haycock
|79||Chapter 4: Principles and Biological Pathways to Tissue Regeneration: The Tissue Regenerative Niche|
Ranieri Cancedda and Claudia Lo Sicco
|115||Chapter 5: Host Response to Biomaterials|
Sangeetha Srinivasan and Julia E. Babensee
|173||Chapter 6: Scaffold Vascularization|
Lindsay E. Fitzpatrick, Alexandra Lisovsky, Ema C. Ciucurel, and Michael V. Sefton
|223||Chapter 7: Engineering Biomimetic Scaffolds|
Nasim Annabi, Nihal Engin Vrana, Pinar Zorlutuna, Fariba Dehghani, and Ali Khademhosseini
|263||Chapter 8: Biomaterials for Scaffolds: Synthetic Polymers|
Luis Rojo, Blanca Vázquez, and Julio San Román
|301||Chapter 9: Biomaterials for Scaffolds: Natural Polymers|
Lindsay S. Wray and David L. Kaplan
|337||Chapter 10: Hydrogels: Characteristics and Properties|
Rolando Barbucci and Daniela Pasqui
|387||Chapter 11: Fabrication Methods of Tissue Engineering Scaffolds|
Vitor M. Correlo, Joaquim M. Oliveira, Ana R. C. Duarte, Albino Martins, Ana L. Oliveira, Joana Silva-Correia, Rui L. Reis, and Nuno M. Neves
|435||Chapter 12: Engineered Scaffolds: Materials and Microstructure from Nanostructures to Macrostructures for Tissue Engineering|
Venu G. Varanasi, Panayiotis S. Shiakolas, and Pranesh B. Aswath
|491||Chapter 13: Organ Printing and Cell Encapsulation|
Savas Tasoglu, Umut Atakan Gurkan, Sinan Guven, and Utkan Demirci
|529||Chapter 14: In vitro and in vivo Testing|
Milena Fini, Nicolò Nicoli Aldini, and Paola Torricelli
|555||Chapter 15: Bioreactor Strategies for in vitro Conditioning of Engineered Tissues|
Aaron S. Goldstein and Patrick Thayer
|591||Chapter 16: Microvascular Imaging Methods for Tissue Engineering|
Benjamin W. Thimm, Sandra Hofmann, and Ralph Müller
|637||Chapter 17: Tissue Engineering: Scope, Products, and Commercialization Strategies|
Arthur J. Coury
Advanced undergraduate- and graduate/post-graduate level students in biomedical engineering, materials engineering, medicine and biology; researchers in materials, biology, and medicine, especially those with an interest in regenerative medicine and tissue engineering.
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