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Drug Delivery and Development of Anti-HIV Microbicides
by Bruno Sarmento (University of Porto, Portugal), José das Neves (University of Porto, Portugal)
Hardback 683 pages 2014-11-30 Print ISBN: 9789814463560 eBook ISBN: 9789814463577 DOI: 10.4032/9789814463577 List price : $249.95
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“HIV prevention requires a multidisciplinary approach, even when focusing on a particular biomedical intervention such as anti-HIV microbicides. This book offers a comprehensive, integrative, and balanced overview on various aspects of microbicides, including mechanisms of transmission, drug development, and clinical and regulatory aspects, with a special emphasis on formulation. It is therefore equally useful for specialized basic, pharmacological, clinical, and biotechnological scientists and will hopefully stimulate future interdisciplinary research for prevention.”
Prof. Guido Vanham - University of Antwerp, Belgium
“This treatise offers an insightful analysis on the opportunities that drug delivery technologies can afford in HIV microbicide development. It provides first-of-its-kind comprehensive overview of the challenges in microbicide delivery as well as opportunities to develop novel formulations such as polymeric implants, stimuli-responsive nanotechnology, and strategies to alter the microbiome. It also addresses the issues of socio-economics, compliance, and regulatory oversight in the development of novel microbicides.”
Prof. Mansoor M. Amiji - Northeastern University, USA
The worldwide impact of HIV/AIDS is well recognized. In the absence of a cure, prophylaxis represents a cornerstone in the battle against infection. One promising strategy comprises the use around the time of sexual intercourse of vaginal/rectal products containing antiviral compounds, termed microbicides. It is now recognized that specific development of drug dosage forms and/or drug delivery systems is an indispensable aspect for the success of microbicides. Different groups strived over the last decade to optimize the biophysical and technological performance of traditional dosage forms (gels, tablets and suppositories) in order to fulfill the specificities of microbicides use, without neglecting users’ preferences and affordability issues. Moreover, new formulation approaches, such as vaginal rings and films, nanotechnology-based systems, stimuli-sensitive formulations, targeted drug delivery systems, among others have been proposed and are currently undergoing pre-clinical or even clinical testing. This book provides for the first time a thorough and critical overview of current aspects, recent developments and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issues related to the subject are discussed.
Access | Page | Title | Price | |
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![]() | Front Matter Download PDF | Free | ||
![]() | 1 | Chapter 1: Microbicides for the Prevention of HIV Osmond J. D’Cruz and Fatih M. Uckun | $25.00 | |
![]() | 55 | Chapter 2: HIV Transmission Models: Lessons Learned for Microbicide Formulation Design Pedro M. M. Mesquita and Betsy C. Herold | $25.00 | |
![]() | 91 | Chapter 3: Challenges in Microbicide Drug Delivery: Identifying Targets and Evolving Strategies Karolin Hijazi, Constandinos Carserides, and Charles Kelly | $25.00 | |
![]() | 117 | Chapter 4: Safety Aspects of Topical Anti-HIV Microbicides Raina N. Fichorova | $25.00 | |
![]() | 151 | Chapter 5: Biophysics, Drug Transport Modeling, and Performance of Microbicides David F. Katz | $25.00 | |
![]() | 193 | Chapter 6: Dosage Forms for Microbicide Formulations: Advantages and Pitfalls Viness Pillay, Pradeep Kumar, Valence M. K. Ndesendo, Yahya E. Choonara, and Lisa du Toit | $25.00 | |
![]() | 221 | Chapter 7: Microbicide Intravaginal Rings John A. Moss and Marc M. Baum | $25.00 | |
![]() | 291 | Chapter 8: Vaginal Microbicide Films Lisa C. Rohan and Wei Zhang | $25.00 | |
![]() | 331 | Chapter 9: The Development of Rectal Microbicides for HIV-1 Prevention Ian McGowan, Charlene S. Dezzutti, and Lisa C. Rohan | $25.00 | |
![]() | 377 | Chapter 10: Design of Stimuli-Sensitive Microbicide Formulations Chi H. Lee and Namita Giri | $25.00 | |
![]() | 415 | Chapter 11: Nanotechnology-Based Systems for Microbicide Development Rute Nunes, Carole Sousa, Bruno Sarmento, and José das Neves | $25.00 | |
![]() | 459 | Chapter 12: Electrospun Fibers for Microbicide Drug Delivery Cameron Ball and Kim A. Woodrow | $25.00 | |
![]() | 509 | Chapter 13: Modified Microbiota for Microbicide Drug Delivery Luca Vangelista and Massimiliano Secchi | $25.00 | |
![]() | 535 | Chapter 14: Microbicide Formulation Development: Scale-Up, Affordability, and Intellectual Property Issues David R. Friend, Bríd Devlin, and Christopher Gilmour | $25.00 | |
![]() | 549 | Chapter 15: Regulatory Issues Pertaining to Microbicide Development Linda Arterburn, Lisa Carlton, and Zeda Rosenberg | $25.00 | |
![]() | 569 | Chapter 16: Socioeconomic and Behavioral Factors Influencing Choice, Adherence, and Success of Microbicide Formulations Elizabeth Tolley, Barbara Friedland, Mitzy Gafos, Rivet Amico, Lut Van Damme, Cynthia Woodsong, Kathleen MacQueen, Leila Mansoor, and Sheena McCormack | $25.00 | |
![]() | Index Download PDF | Free |
Scientists engaged in HIV research and prophylaxis, vaginal and rectal drug delivery, drug development, pharmaceutical regulatory science, and socioeconomic and behavioral research pertaining sexually transmitted diseases; Graduate-level students in the fields of HIV/AIDS and sexually transmitted diseases.