edited by Yuriy Gusev (University of Oklahoma, USA)

The recent discovery of microRNAs - a new class of non-coding RNAs - has revolutionized modern biomedical sciences. This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology and mathematical modeling.

This volume contains adaptations and critical reviews of the recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of miRNA regulation are also discussed.

Contents:

• Measurement and Interpretation of MicroRNA Expression Profiles (B Curry & R Ach)
• MicroRNA Expression Analysis by LNA Enhanced Microarrays (R Søkilde et al.)
• Analysis and QC for Real-Time QPCR Arrays of Human MicroRNAs (D P Dittmer et al.)
• Massively Parallel MicroRNA Profiling in the Haematologic Malignancies (R D Morin et al.)
• Who Dunit? MicroRNAs Involved in Prostate Cancer (H K Chang)
• Intronic MicroRNA: Creation, Evolution and Regulation (S Barik & T Barik)
• MiRome Architecture and Genomic Instability (K Huppi et al.)
• Interconnection of MicroRNA and Transcription Factor-Mediated Regulatory Networks (Y-M Zhou)
• Analysis of MicroRNA Profiling Data with Systems Biology Tools (Y Gusev et al.)
• Mathematical and Computational Modeling of Post-Transcriptional Gene Regulation by MicroRNAs (R Khanin & D J Higham)

Readership: A broad audience of academic, and biotech and pharmaceutical industry biomedical scientists, physicians involved in cancer research, oncologists, computational biologists, and bioinformaticians who are involved in basic, translational and clinical research as well as college educators, undergraduate and graduate and medical students.

"Topics on microRNAs have taken scientists by storm in the last seven years. Today more than 5500 publications related to microRNAs can be found in PubMed. Do we really need another book for readers already saturated with this topic? The answer is a definite yes. Yuriy Gusev has wisely put together a fine book linking various aspects of the study of microRNAs starting with profiling of microRNoma, the functional study of pathway networks involving miRNAs as well as evolutionary models of microRNoma evolution or mathematical models of posttranscriptional regulation of microRNAs. Readers will find the book microRNA Profiling in Cancer - A Bioinformatics Perspective different as compared with others already published. One thing for certain the curiosity of the readers will increase with every page turned."

272pp		Oct 2009
978-981-4267-01-4		US$129