DENDRIMER-BASED NANOMEDICINE

edited by Istvan Majoros & James Baker, Jr. (University of Michigan, USA)

Table of Contents (108k)
Preface (809k)
Chapter 1: Targeted Drug Deliveryin General, New Technologyin Medicine (93k)

In recent decades, dendrimers — free-shaped synthetic macromolecules — have garnered a great deal of scientific interest due to their unique molecular nanostructure. Used in a variety of scientific applications, the use of dendrimers is now widely regarded as a safer, more precise, and more effective way to practice medicine.

This book compiles and details cutting-edge research in science and medicine from the interdisciplinary team of the Michigan Nanotechnology Institute for Medicine and Biological Sciences, who are currently revolutionizing drug delivery techniques through the development of engineered nanodevices. Edited by Istvan J Majoros and James Baker, Jr., two prominent nanotechnology researchers, this book will appeal to anyone involved in nanotechnology, macromolecular science, cancer therapy, or drug delivery research.

Contents:

• Targeted Drug Delivery in General, New Technology in Medicine (B B Ward & J R Baker, Jr.)
• General Carriers for Drug Delivery (T H Dunham et al.)
• Poly(amidoamine) Dendrimer Synthesis and Characterization (I J Majoros & D E Carter)
• Optical and Biophotonic Applications of Dendrimer Conjugate (J Y Ye & T B Norris)
• Dendrimer Conjugates for Cancer Treatment (I J Majoros et al.)
• Biological Application of PAMAM Dendrimer Nanodevices in vitro and in vivo (T P Thomas & J F Kukowska-Latallo)
• Dendrimer-based Targeted Apoptosis Sensors for Medical Application (A Myc et al.)
• MRI Using Targeted Dendrimer Contrast Agents (S D Swanson & C R Williams)
• Nanoparticle — Membrane Interactions: Mechanism for Enhanced Permeability (S Hong et al.)
• Computer Simulations of Dendrimers (S K Kandasamy et al.)
• Dendrimer-Entrapped and Dendrimer-Stabilized Metal Nanoparticles for Biomedical Applications (X-Y Shi & S H Wang)

Readership: Advanced undergraduate- and graduate-level students in nanotechnology; researchers in macromolecular science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in drug delivery or cancer therapy.

"The authors' approach to fill in a little history with futuristic perspective will be a delight to all readers interested in the field. A must read." George R Newkome Vice President for Research & Dean, Graduate School The University of Akron, USA

Key Features:

• Covers research on polyamidoamine (PAMAM) dendrimer-based nanodevices for use in nanomedicine, including aspects from chemistry, biology, various diagnostic methodologies, and computer simulation
• Includes contributions from and is coedited by Dr James Baker, Jr, MD, an international leader in biological nanotechnology and a member of the Nanotechnology Technical Advisory Group of the President's Council of Advisors on Science and Technology
• Illustrated throughout with excellent figures and references to accompany each section

436pp		May 2008
978-981-4241-04-5		US$215